High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: Interaction with IQ motif-containing factors

Tyler Robinson, Melody Pai, Jeff Liu, Frederick Vizeacoumar, Thomas Sun, Sean Egan, Alessandro Datti, Jing Huang, Eldad Zacksenhaus. (2013) High-throughput screen identifies disulfiram as a potential therapeutic for triple-negative breast cancer cells: Interaction with IQ motif-containing factors. Cell Cycle DOI: http://dx.doi.org/10.4161/cc.26063

Identification of Direct Protein Targets of Small Molecules

Brett Lomenick, Richard W. Olsen, Jing Huang. (2010) Identification of Direct Protein Targets of Small Molecules. ACS Chem. Biol. DOI: 10.1021/cb100294v

Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick, Rui Hao, Nao Jonai, Randall M. Chin, Mariam Aghajan, Sarah Warburton, Jianing Wang, Raymond P. Wu, Fernando Gomez, Joseph A. Loo, James A. Wohlschlegel, Thomas M. Vondriska, Jerry Pelletier, Harvey R. Herschman, Jon Clardy, Catherine F. Clarke, Jing Huang. (2009) Target identification using drug affinity responsive target stability (DARTS). PNAS DOI: 10.1073/pnas.0910040106

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

Mariam Aghajan, Nao Jonai, Karin Flick, Fei Fu, Manlin Luo, Xiaolu Cai, Ikram Ouni, Nathan Pierce, Xiaobo Tang, Brett Lomenick, Robert Damoiseaux, Rui Hao, Pierre M del Moral, Rati Verma, Ying Li, Cheng Li, Kendall N Houk, Michael E Jung, Ning Zheng, Lan Huang, Raymond J Deshaies, Peter Kaiser, Jing Huang. (2010) Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nature Biotechnology DOI: 10.1038/nbt.1645

Target Identification Using Drug Affinity Responsive Target Stability (DARTS)

Brett Lomenick, Gwanghyun Jung, James A. Wohlschlegel. Jing Huang. (2011) Target Identification Using Drug Affinity Responsive Target Stability (DARTS). Current Protocols in Chemical Biology DOI: 10.1002/9780470559277.ch110180

The Chemistry and Biology of Nakiterpiosin – C-nor-D-Homosteroids

Shuanhu Gaoa, Qiaoling Wanga, Gelin Wanga, Brett Lomenick, Jie Liuc, Chih-Wei Fand, Lih-Wen Dengc, Jing Huangb, Lawrence Lumd, Chuo Chen. (2012) The Chemistry and Biology of Nakiterpiosin – C-nor-D-Homosteroids. Synlette DOI: 10.1055/s-0031-1290460

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

Xudong Fu, Randall M. Chin, Laurent Vergnes, Heejun Hwang, Gang Deng, Yanpeng Xing, Melody Y. Pai, Sichen Li, Lisa Ta, Farbod Fazlollahi, Chuo Chen, Robert M. Prins, Michael A. Teitell, David A. Nathanson, Albert Lai, Kym F. Faull, Meisheng Jiang, Steven G. Clarke, Timothy F. Cloughesy, Thomas G. Graeber, Daniel Braas, Heather R. Christofk, Michael E. Jung, Karen Reue, Jing Huang. 2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling. (2016) Cell Metabolism DOI

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

Randall M. Chin, Xudong Fu, Melody Y. Pai, Laurent Vergnes, Heejun Hwang, Gang Deng, Simon Diep, Brett Lomenick, Vijaykumar S. Meli, Gabriela C. Monsalve, Eileen Hu, Stephen A. Whelan, Jennifer X. Wang, Gwanghyun Jung, Gregory M. Solis, Farbod Fazlollahi, Chitrada Kaweeteerawat, Austin Quach, Mahta Nili, Abby S. Krall, Hilary A. Godwin, Helena R. Chang, Kym F. Faull, Feng Guo, Meisheng Jiang, Sunia A. Trauger, Alan Saghatelian, Daniel Braas, Heather R. Christofk, Catherine F. Clarke, Michael A. Teitell, Michael Petrascheck, Karen Reue, Michael E. Jung, Alison R. Frand, Jing Huang. (2014) The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature.com

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

Tohda, C., Urano, T., Umezaki, M., Nemere, I. & Kuboyama, T. Diosgenin is an exogenous activator of 1,25D(3)-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice. Scientific Reports 2(2012).